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Published on: November 20, 2015
Neurodevelopmental impairment in preterm infants following progressive post-hemorrhagic ventricular dilatation
Grace M Musiime1, Leonora Hendson1,2, Khorshid Mohammad1,2
1Department of Pediatrics, Section of Newborn Critical Care, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Objective:
To investigate the relationship of post-hemorrhagic ventricular dilatation (PHVD) with neurodevelopmental outcomes in preterm infants.
Study Design:
Retrospective cohort study of infants <29 weeks' gestation admitted from 2010-2018 with intraventricular hemorrhage and neurodevelopmental assessment at 18-21 months corrected age. Eligible infants were grouped as 'no PHVD', 'PHVD without neurosurgical intervention', and 'symptomatic PHVD with intervention'. Neurodevelopmental impairment (NDI) was assessed using generalized linear models.
Results:
Of 227 infants, 183 (80.6%) had no PHVD, 28 (12.3%) had PHVD without intervention, and 16 (7.0%) had PHVD with intervention. Severe NDI was observed in 14 (7.7%), 10 (35.7%), and 10 (62.5%) infants, respectively (p < 0.05). PHVD without and with intervention was associated with significantly increased risk of overall NDI (adjusted odds ratios [aOR] 6.2, 95% CI 2.4-16.5 and 18.1, 95% CI 5.5-68.4) as compared to no PHVD.
Conclusions:
Progressive PHVD, irrespective of clinical symptoms, predisposes affected preterm infants to significant risk of NDI.
