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Updated: Mar 15, 2026

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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
364
RAMPA Therapy: Effects on Craniofacial Growth Assessed by Coben Analysis and Statistical Evaluation
Yasushi Mitani1, Yuko Okai-Kojima2, Takahisa Shimazaki3
1Codomo Clinic, Tokyo 180-0004, Japan.
Journal of Clinical Medicine
|March 14, 2026
Summary
The Right Angle Maxillary Protraction Appliance (RAMPA) system effectively promotes anterosuperior craniofacial growth and induces favorable mandibular rotation in growing patients with skeletal Class III malocclusion.
Area of Science:
- Orthodontics and Craniofacial Development
- Skeletal Malocclusion Research
- Orthopedic Maxillary Protraction
Background:
- Maxillary hypoplasia and skeletal Class III malocclusion present significant challenges in pediatric growth.
- Conventional orthopedic treatments may lead to undesirable posteroinferior displacement.
- The Right Angle Maxillary Protraction Appliance (RAMPA) system offers a novel approach to anterosuperior maxillary protraction.
Purpose of the Study:
- To investigate the craniofacial growth effects of the RAMPA system.
- To evaluate RAMPA's potential in mitigating adverse effects of conventional Class III treatments.
- To assess changes in facial depth, anterior facial height, and mandibular rotation.
Main Methods:
- Retrospective comparative cohort study of 30 growing patients (17 males, 13 females).
- Coben analysis of cephalometric measurements before (T1) and after (T2) RAMPA treatment.
- Statistical analysis using paired t-tests or Wilcoxon signed-rank tests (α = 0.05).
Main Results:
- Significant increases in facial depth (Ba-N) and anterior facial height (N-Me) observed in both sexes.
- Males showed a significant decrease in the Gonial Angle, indicating anterior mandibular rotation.
- Females exhibited a significant increase in the maxillary depth ratio (Ptm-A/Ba-N).
Conclusions:
- RAMPA treatment effectively promotes anterosuperior craniofacial growth.
- The system induces favorable mandibular rotation, beneficial for skeletal Class III malocclusion.
- RAMPA shows potential clinical value for enhancing craniofacial balance.
Keywords:
Coben analysisRAMPAcraniofacial growthmaxillary hypoplasiaretrospective cohort studyskeletal Class III malocclusion
