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Updated: Mar 15, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

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Periodization in Orthobiologics Rehabilitation.

Georgios Kakavas¹, George Skarpas², Trifon Totlis^3,4

¹Fysiotek Spine & Sports Lab, 17562 Athens, Greece.

Journal of Clinical Medicine

|March 14, 2026

Summary

This study introduces a neuroplastic periodized rehabilitation approach for orthobiologic treatments. It aligns recovery phases with healing stages to enhance functional outcomes for athletes and non-athletes.

Keywords:

mesocycles neuroplasticity orthobiologics periodization rehabilitation

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A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

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Published on: November 6, 2015

Area of Science:

Orthopedics
Regenerative Medicine
Sports Rehabilitation

Background:

Orthobiologic treatments like platelet-rich plasma and stem cell therapies are gaining traction for musculoskeletal healing.
Current rehabilitation protocols often lack a structured, progressive framework aligned with biological healing processes.

Purpose of the Study:

To propose a neuroplastic periodized rehabilitation model for patients undergoing orthobiologic interventions.
To enhance functional recovery and optimize outcomes in both athletic and non-athletic populations.

Main Methods:

The proposed model integrates periodization principles from athletic training into rehabilitation.
It structures recovery into sequential phases mirroring biological healing stages.
Emphasis is placed on pain control, progressive loading, and neuroplastic adaptations.

Main Results:

The periodized approach allows for individualized progression based on patient recovery and response to loading.
It aims to maximize regenerative potential by aligning rehabilitation with intrinsic healing processes.
The model facilitates the integration of physiological and neuromuscular goals for comprehensive recovery.

Conclusions:

A neuroplastic periodized approach offers a structured, evidence-informed framework for regenerative rehabilitation.
This model can guide clinicians in delivering patient-centered care after orthobiologic procedures.
It has the potential to standardize care and improve functional outcomes across diverse patient groups.