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Updated: Mar 15, 2026

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

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Less-Invasive Hemodynamic and Tissue Perfusion Monitoring in Sepsis and Septic Shock: A Narrative Review.

Marialaura Scarcella¹, Paolo Formenti², Gian Marco Petroni¹

¹Anesthesia, Intensive Care and Nutritional Science, Azienda Ospedaliera "Santa Maria", Via Tristano di Joannuccio, 05100 Terni, Italy.

Journal of Clinical Medicine

|March 14, 2026

Summary

Monitoring sepsis and septic shock patients is crucial. Less-invasive hemodynamic and tissue perfusion monitoring strategies are evolving to improve resuscitation and patient outcomes.

Keywords:

critical care hemodynamic monitoring less-invasive monitoring sepsis septic shock tissue perfusion

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Last Updated: Mar 15, 2026

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Published on: December 10, 2020

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Published on: November 3, 2023

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Published on: May 21, 2019

Area of Science:

Critical Care Medicine
Cardiology
Physiology

Background:

Sepsis and septic shock are leading causes of death in critically ill patients.
Hemodynamic management is vital, but optimal monitoring remains debated.
There's a shift from invasive to less-invasive monitoring techniques.

Purpose of the Study:

To review current evidence on less-invasive hemodynamic and tissue perfusion monitoring in sepsis.
To discuss the physiological basis of these monitoring methods.
To explore their role in modern resuscitation strategies.

Main Methods:

Narrative review of existing literature.
Analysis of current evidence on less-invasive monitoring technologies.
Discussion of physiological rationale and clinical application.

Main Results:

Less-invasive technologies enable continuous cardiovascular assessment.
Focus is shifting to tissue perfusion and oxygenation beyond macrocirculation.
Normalization of hemodynamics doesn't guarantee adequate microcirculation.

Conclusions:

Less-invasive monitoring offers valuable insights into sepsis hemodynamics and perfusion.
These methods are increasingly important for guiding multimodal resuscitation.
Further research is needed to optimize their integration into clinical practice.