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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Radiomics-Based Characterization of Aggressive Prostate Cancer Variants: Diagnostic Challenges and Opportunities.

Katarzyna Sklinda1, Martyna Rajca1, Marek Kasprowicz2

  • 1Centre of Radiological Diagnostics, National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland.

Cancers
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Aggressive prostate cancer variants present diagnostic challenges. Radiomics can improve early detection and risk stratification by analyzing imaging features, complementing conventional methods.

Keywords:
Gleason pattern 5aggressive prostate cancer variantsductal adenocarcinomaimaging biomarkersmultiparametric MRIneuroendocrine prostate cancerradiomicsreviewsmall cell carcinomatumor heterogeneity

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Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Aggressive prostate cancer variants exhibit atypical imaging, variable PSA behavior, and distinct molecular profiles, challenging diagnosis and prognosis.
  • Conventional imaging may underestimate the aggressiveness of these variants.
  • Understanding their unique characteristics is crucial for accurate risk stratification.

Purpose of the Study:

  • To review current evidence on imaging characteristics, biomarker dynamics, and radiomic features of aggressive prostate cancer variants.
  • To evaluate the role of radiomics in the early recognition and risk stratification of these challenging subtypes.

Main Methods:

  • A structured narrative review of studies on aggressive prostate cancer variants.
  • Inclusion of multiparametric MRI, PET (PSMA, FDG), bone scintigraphy, and ultrasound.
  • Extraction of data on PSA, tumor location, size, metastatic patterns, and molecular alterations.

Main Results:

  • Neuroendocrine and small cell carcinomas often present with low PSA, high FDG uptake, and central location.
  • Ductal adenocarcinoma shows restricted diffusion and elevated PSA; basal cell carcinoma can be inconspicuous.
  • Radiomic analysis effectively captures tumor heterogeneity and complexity.

Conclusions:

  • Aggressive prostate cancer variants are often missed by routine imaging.
  • Radiomics provides quantitative insights for improved early detection and subtype differentiation.
  • Further prospective and radiogenomic studies are needed to validate radiomics' role.