Prospective Multimodal Assessment of Radiation-Induced Subclinical Cardiac Changes in Patients with Left Breast...

This prospective study aimed to investigate asymptomatic microscopic changes in the myocardium following postoperative radiation therapy (RT) in patients with left breast cancer using multi-medical assessment techniques.

This study included 16 left-sided breast cancer patients who received postoperative RT between January 2021 and December 2022 at our institution. Cardiac examinations were performed before RT and at 1, 12, 24, and 48 weeks after RT. We conducted comparative analyses between pre-RT and various post-RT time points, exploring correlations between changes in hematologic biomarkers, global longitudinal strain (GLS), and myocardial metabolism.

Inflammatory biomarkers such as the neutrophil-lymphocyte, platelet-lymphocyte, and lymphocyte-monocyte ratios changed between the pre- and post-RT periods but returned to normal levels after several months. However, troponin T and soluble suppression of tumorigenicity 2 showed sustained changes during the 1-year follow-up period. Among echocardiographic parameters, GLS_LAX showed a significant difference between pre-RT and post-RT assessments. Additionally, irradiated and non-irradiated myocardial metabolic ratios on ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography differed between pre-RT and post-RT and remained altered up to one year after treatment.

These findings suggest that subclinical myocardial changes may persist following RT, although the clinical significance of subclinical myocardial changes remains uncertain and warrants further investigation.