OSIRIS-Nose: Organ Sparing Using Interventional Radiotherapy (Brachytherapy) for Invasive Squamous Cell Cancer of the...

Area of Science:

• Oncology
• Radiation Oncology
• Surgical Oncology

Background:

• Squamous cell carcinoma of the nasal vestibule (SCCNV) is a rare cancer.
• Traditional treatment involves radical surgery, often causing significant functional and aesthetic issues.
• An organ-preserving approach integrating high-dose-rate interventional radiotherapy (HDR-IRT) with surgery is explored.

Purpose of the Study:

• To evaluate the efficacy of a combined HDR-IRT and organ-preserving surgery approach for SCCNV.
• To assess organ preservation rates, disease control, toxicity, and cosmetic outcomes.

Main Methods:

• Retrospective analysis of 51 patients with primary SCCNV treated between 2008-2022.
• Intraoperative interstitial HDR-IRT catheter implantation with a median total dose of 40 Gy.
• Combined with gross total resection (7 patients) or subtotal resection (44 patients).

Main Results:

• A 5-year nose preservation rate of 90% was achieved.
• Local control was 84%, regional failure-free survival was 94%, and overall survival was 82%.
• Manageable toxicity with 84.3% satisfactory cosmetic outcomes at 3 years.

Conclusions:

• The OSIRIS approach (HDR-IRT with organ-preserving surgery) is effective for SCCNV.
• It offers high rates of organ preservation and long-term disease control.
• The treatment demonstrates manageable toxicity and positive cosmetic results.