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Updated: Mar 15, 2026
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
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CD57-Expressing Lymphocytes: From Chronic Viral Response to Age-Related Inflammation.
Isabel María Vallejo-Bermúdez1,2, Mabel Rocio Miranda-Echagüe1, Silvia Fernández-Álvarez2
1Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Av. Menendez Pidal s/n, 14004 Cordoba, Spain.
Cells
|March 14, 2026
Summary
CD57-expressing lymphocytes, often found in chronic viral infections like CMV, accumulate with age. These terminally differentiated cells contribute to immune aging and dysregulation, offering potential therapeutic targets.
Area of Science:
- Immunology
- Cell Biology
- Gerontology
Background:
- CD57-expressing lymphocytes are immune cells with heightened cytotoxic and pro-inflammatory functions.
- Initially linked to chronic viral infections such as cytomegalovirus (CMV), they are now recognized in immunosenescence and immune dysregulation.
- Their accumulation signifies prolonged antigen exposure and immune activation, disrupting immune homeostasis.
Purpose of the Study:
- To review the characteristics of CD57+ lymphocytes.
- To examine their association with chronic viral infections and aging.
- To explore their role in age-related diseases and potential therapeutic strategies.
Main Methods:
- Literature review of phenotypic and functional characteristics.
- Analysis of associations with viral infections and aging.
- Exploration of implications for age-related diseases.
Main Results:
- CD57 expression marks terminally differentiated T and NK cells.
- These cells exhibit enhanced cytotoxicity, altered cytokine secretion, and a pro-inflammatory phenotype.
- Accumulation of CD57+ lymphocytes correlates with chronic infections and immune aging.
Conclusions:
- CD57+ lymphocytes play a significant role in chronic viral infections and immunosenescence.
- Understanding their biology may reveal insights into immune aging.
- These cells represent potential targets for therapies to restore immune balance in older adults.
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