Related Experiment Video
Updated: Mar 15, 2026
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
Machine Learning-Driven Multi-Omics Analysis Identifies CHP2 as a Key PANoptosis-Related Dual-Function Biomarker in
Zetian Zhang1, Xingyu Jiang1, Xin Zhang1
1The Key Laboratory of Zoonosis, Department of Pathogen Biology, Chinese Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun 130000, China.
Abstract:
The heterogeneity of colorectal cancer (CRC) represents a great challenge in therapy. We integrated multiomics and machine learning, interpreted by SHAP models to provide a clinical rationale, to identify Calcineurin B Homologous Protein 2 (CHP2) as a core candidate, which was further validated via in vitro and zebrafish models. The expression of CHP2 are decreased in CRC, which is associated with a poor prognosis and an immune suppressed "cold" TIME. Functionally, CHP2 overexpression inhibits cell growth and invasion by inducing PANoptosis. Clinically, specific CHP2 expression profiles discriminate patients at high risk that are resistant to standard chemotherapy (e.g., 5-FU) but sensitive to targeted inhibitors. CHP2 is a powerful dual-function biomarker-prognostic for survival and predictive for the response to therapy-that could lead to a personalized approach in treating drug-resistant CRC.
