Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Cohort-Based Genetic Analysis of Keratoconus in Turkey Reveals a Substantial Proportion of Novel Variants and Suggests Possible Oligogenic Contributions to Keratoconus.

Genes·2026
Same author

Parental awareness of screen use and myopia risk in children: a study among Turkish parents.

Frontiers in public health·2026
Same author

Evaluation of regression, reactivation, retreatment and retinal detachment after injections of three different anti-VEGF drugs for retinopathy of prematurity.

Scientific reports·2026
Same author

Analysis of indications, intraoperative findings, and audiologic outcomes of pure endoscopic revision stapes surgery: A multicenter study.

Auris, nasus, larynx·2026
Same author

Voice Disorders Across Age Subgroups in the Geriatric Population: A Retrospective Observational Study.

Ear, nose, & throat journal·2026
Same author

Effects of strabismus surgery on static and dynamic pupillometry.

Strabismus·2026

Related Experiment Video

Updated: May 13, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

8.9K

Is Macular Telangiectasia Type 2 Associated with Hearing Loss and Cochlear Dysfunction? A Prospective Case-Control

Yeşim Yüksel1, Muhammet Yıldız1, Muhammet Kazım Erol2

  • 1Department of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Sciences, 07100 Antalya, Turkey.

Diagnostics (Basel, Switzerland)
|March 14, 2026
PubMed
Summary

Macular telangiectasia type 2 (MacTel2) is linked to significant hearing loss, particularly in higher frequencies. Auditory screening may be beneficial for MacTel2 patients, revealing cochlear dysfunction.

Keywords:
audiometryauditorybrain stemcochleaevoked potentialshearing lossmacular telangiectasiaotoacoustic emissionspure-tonesensorineuralspontaneous

More Related Videos

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.3K
Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

2.3K

Related Experiment Videos

Last Updated: May 13, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

8.9K
Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.3K
Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

2.3K

Area of Science:

  • Ophthalmology
  • Audiology
  • Neuroscience

Background:

  • Macular telangiectasia type 2 (MacTel2) is a progressive retinal disorder with potential systemic links.
  • Cochlear structures are susceptible to microvascular and metabolic stressors, suggesting a possible connection to MacTel2.

Purpose of the Study:

  • To investigate the association between Macular telangiectasia type 2 (MacTel2) and auditory dysfunction.
  • To determine if MacTel2 patients exhibit measurable hearing impairment compared to healthy controls.

Main Methods:

  • Prospective case-control study with 21 MacTel2 patients and 21 matched controls.
  • Comprehensive audiological assessment including pure-tone audiometry (0.5-16 kHz), distortion product otoacoustic emissions (DPOAE), and auditory brainstem response (ABR).
  • Hearing loss graded using WHO criteria and a clinical cutoff (PTA4 > 25 dB HL).

Main Results:

  • MacTel2 patients showed significantly higher hearing thresholds across conventional and extended high frequencies compared to controls.
  • Reduced DPOAE amplitudes and increased DPOAE absence were observed in MacTel2 patients, indicating cochlear dysfunction.
  • Auditory brainstem response (ABR) parameters were comparable between groups, suggesting preserved central auditory pathways.

Conclusions:

  • Macular telangiectasia type 2 (MacTel2) is associated with peripheral auditory impairment, primarily affecting the cochlea.
  • Findings support the role of outer hair cell dysfunction in MacTel2.
  • Auditory screening, including extended high-frequency audiometry and DPOAE, may be clinically relevant for MacTel2 patients.