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Mesoporous Bioactive Glasses: A Review on Structure-Directing-Based Synthesis, Characterization, and Biomedical

Adriana Vulpoi1,2, Ioan Botiz2,3

  • 1Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, 400271 Cluj-Napoca, Romania.

Materials (Basel, Switzerland)
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Mesoporous bioactive glasses (MBGs) offer advanced bone regeneration and drug delivery due to their unique nanostructure. Tailoring their composition and synthesis enhances therapeutic ion release and tissue healing capabilities.

Keywords:
biomedical applicationsmesoporous bioactive glasssol–gel evaporation-induced self-assemblystructure directing agent

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Mesoporous bioactive glasses (MBGs) integrate traditional bioactive glass properties with controlled nanostructure.
  • Their high surface area and tunable porosity enhance drug delivery and tissue regeneration.

Purpose of the Study:

  • To highlight the synthesis, functionalization, and biomedical applications of MBGs.
  • To explore how structural and compositional control influences MBG performance.

Main Methods:

  • Synthesis guided by structure-directing agents.
  • Compositional tailoring via therapeutic ion doping (Sr, Cu, Zn, B).
  • Comprehensive characterization correlating structure with biological outcomes.

Main Results:

  • MBGs exhibit enhanced drug loading, controlled ion release, and accelerated tissue regeneration.
  • Doping imparts specific functionalities like osteogenesis, angiogenesis, and antibacterial activity.
  • Versatile applications in bone tissue engineering, drug delivery, and wound healing.

Conclusions:

  • MBGs offer significant potential in diverse biomedical fields.
  • Challenges include scalability, reproducibility, and predicting in vivo behavior.
  • Future directions involve eco-friendly synthesis, smart MBGs, and additive manufacturing.