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Mesoporous Bioactive Glasses: A Review on Structure-Directing-Based Synthesis, Characterization, and Biomedical
Adriana Vulpoi1,2, Ioan Botiz2,3
1Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, 400271 Cluj-Napoca, Romania.
Materials (Basel, Switzerland)
|March 14, 2026
Summary
Mesoporous bioactive glasses (MBGs) offer advanced bone regeneration and drug delivery due to their unique nanostructure. Tailoring their composition and synthesis enhances therapeutic ion release and tissue healing capabilities.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Mesoporous bioactive glasses (MBGs) integrate traditional bioactive glass properties with controlled nanostructure.
- Their high surface area and tunable porosity enhance drug delivery and tissue regeneration.
Purpose of the Study:
- To highlight the synthesis, functionalization, and biomedical applications of MBGs.
- To explore how structural and compositional control influences MBG performance.
Main Methods:
- Synthesis guided by structure-directing agents.
- Compositional tailoring via therapeutic ion doping (Sr, Cu, Zn, B).
- Comprehensive characterization correlating structure with biological outcomes.
Main Results:
- MBGs exhibit enhanced drug loading, controlled ion release, and accelerated tissue regeneration.
- Doping imparts specific functionalities like osteogenesis, angiogenesis, and antibacterial activity.
- Versatile applications in bone tissue engineering, drug delivery, and wound healing.
Conclusions:
- MBGs offer significant potential in diverse biomedical fields.
- Challenges include scalability, reproducibility, and predicting in vivo behavior.
- Future directions involve eco-friendly synthesis, smart MBGs, and additive manufacturing.
