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Bioplastics01:27

Bioplastics

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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Updated: Apr 30, 2026

Characterization of Full Set Material Constants and Their Temperature Dependence for Piezoelectric Materials Using Resonant Ultrasound Spectroscopy
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Preparation, Biocompatibility, and In Vitro Bioactivity of High-Entropy Bio-Piezoelectric Ceramics.

Huaizhang Gu1, Yuanxun Li1,2, Yunfei Kai1

  • 1College of Science, Kaili University, Kaili 556011, China.

Materials (Basel, Switzerland)
|March 14, 2026
PubMed
Summary

High-entropy ceramics show promise for biomedical uses. Novel (Bi½Na½)(Zr⅓Sn⅓Ti⅓)O₃ (BNZST) and (Bi½Na½)(Zr¼Sn¼Hf¼Ti¼)O₃ (BNZSHT) ceramics exhibit good biocompatibility and piezoelectric properties for bone repair.

Keywords:
biocompatibilityhigh entropyin vitro bioactivitypiezo-bioceramics

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Ceramics

Background:

  • High-entropy strategies enhance functional properties of piezoelectric ceramics.
  • Piezoelectric ceramics are crucial for biomedical applications, including bone repair.

Purpose of the Study:

  • To design and synthesize novel high-entropy ceramics: (Bi½Na½)(Zr⅓Sn⅓Ti⅓)O₃ (BNZST) and (Bi½Na½)(Zr¼Sn¼Hf¼Ti¼)O₃ (BNZSHT).
  • To evaluate their phase structure, surface morphology, biocompatibility, and in vitro bioactivity for potential bone repair applications.

Main Methods:

  • Two-step solid-state reaction synthesis.
  • Characterization of phase structure and surface morphology.
  • In vitro biocompatibility and bioactivity testing using murine fibroblasts (L929).

Main Results:

  • Both BNZST and BNZSHT ceramics adopted perovskite structures with even crystallite sizes and element distribution.
  • Achieved significant piezoelectric properties (d₃₃ ≥ 78 pC/N).
  • Demonstrated high relative cell growth rates (>80%) and enhanced fibroblast proliferation, especially for polarized BNZST.

Conclusions:

  • Multi-element doping and entropy stabilization offer a novel pathway for developing high-entropy bio-piezoelectric ceramics.
  • BNZST and BNZSHT exhibit excellent biocompatibility and bioactivity.
  • These ceramics show potential for use in bone repair materials.