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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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TCGA-Informed Spatial Profiling Reveals Peripheral CD147 Expression at the Invasive Tumor Front as a Prognostic

Felix Nieberle1, Steffen Spoerl1, Quirin Strotzer2

  • 1Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

International Journal of Molecular Sciences
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Low CD147 glycoprotein expression at the oral squamous cell carcinoma invasive front indicates better survival. CD147

Keywords:
BasiginCD147TCGAbiomarkerimmune evasionoral squamous cell carcinomaprognosistherapy resistancetissue microarraytumor microenvironment

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Oral squamous cell carcinoma (OSCC) is a leading cause of cancer mortality with limited prognostic tools.
  • CD147, a membrane glycoprotein, is involved in tumor progression, immune evasion, and therapy resistance.

Purpose of the Study:

  • To investigate the prognostic and predictive value of CD147 expression in different OSCC compartments.
  • To explore CD147's association with survival, clinicopathological parameters, and therapy response.

Main Methods:

  • Immunohistochemistry on 229 OSCC patient samples to assess CD147 expression in tumor center, periphery, and adjacent mucosa.
  • Statistical analyses including Kaplan-Meier and Cox regression.
  • Transcriptomic and immunological analyses using TCGA, UALCAN, TISIDB, and GTEx datasets.

Main Results:

  • Low CD147 expression in the tumor invasive front was an independent predictor of improved overall survival.
  • CD147 expression in the tumor center or mucosa did not show prognostic value.
  • No significant association was found between CD147 expression and adjuvant therapy response.
  • TCGA data confirmed CD147 overexpression and its link to immunosuppression and therapy resistance.

Conclusions:

  • CD147 expression in the tumor periphery is a compartment-specific prognostic marker for OSCC.
  • CD147's role in immune modulation and therapy resistance suggests its potential as a biomarker and therapeutic target.