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Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
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Special Issue "Advances in Retinal Diseases: 2nd Edition".
Minzhong Yu1,2,3
1Department of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106, USA.
International Journal of Molecular Sciences
|March 14, 2026
Summary
Retinal diseases cause vision loss by affecting the eye's complex biology. Understanding these conditions is crucial for developing effective treatments.
Area of Science:
- Ophthalmology and molecular biology
- Neuroscience and genetics
Background:
- Retinal diseases represent a significant challenge in clinical and scientific research.
- These conditions involve intricate biological processes within the retina, leading to irreversible vision impairment.
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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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