Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

93
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
93
Translation01:31

Translation

21.5K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
21.5K
Translation01:31

Translation

159.2K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
159.2K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

63
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
63
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

90
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
90
Translational Regulation01:29

Translational Regulation

754
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
754

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.

Cell reports·2025
Same author

Phytochemicals for High-Throughput Screening in Drug Discovery: Ever Thought of Sprouts?

Drug discovery today·2025
Same author

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

Nature structural & molecular biology·2025
Same author

Targeting AGAT gene expression - a drug screening approach for the treatment of GAMT deficiency.

Expert opinion on drug discovery·2024
Same author

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling.

bioRxiv : the preprint server for biology·2024
Same author

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters.

Nature communications·2024

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Polysome Profiling Protocol for Studying Translational Regulation in Arabidopsis Under Heat Stress
08:39

Author Spotlight: Polysome Profiling Protocol for Studying Translational Regulation in Arabidopsis Under Heat Stress

Published on: October 11, 2024

2.2K

Curcumin Between Pleiotropic Potential and Translational Constraints.

Alessandro Magini1, Alessandro Datti1

  • 1Department of Agricultural, Food, and Environmental Sciences, University of Perugia, 06121 Perugia, Italy.

International Journal of Molecular Sciences
|March 14, 2026
PubMed
Summary

Curcumin

Keywords:
biomarkerscurcuminnutraceuticalspharmacokineticspleiotropysystems pharmacologytranslational constraints

More Related Videos

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

15.3K
Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
10:00

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

Published on: October 28, 2014

29.0K

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Polysome Profiling Protocol for Studying Translational Regulation in Arabidopsis Under Heat Stress
08:39

Author Spotlight: Polysome Profiling Protocol for Studying Translational Regulation in Arabidopsis Under Heat Stress

Published on: October 11, 2024

2.2K
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

15.3K
Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
10:00

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

Published on: October 28, 2014

29.0K

Area of Science:

  • Pharmacology
  • Biochemistry
  • Microbiome Research

Background:

  • Curcumin is traditionally known for anti-inflammatory and antioxidant effects.
  • This view overlooks its complex, multi-layered pharmacology.
  • Its actions are context-dependent and involve intricate biological networks.

Purpose of the Study:

  • To present a refined perspective on curcumin's pharmacology.
  • To explain its network-level modulation and context-dependent outcomes.
  • To propose a framework for interpreting pleiotropic bioactive compounds.

Main Methods:

  • Hierarchical and multilayered architectural analysis of curcumin's pharmacology.
  • Integration of intrinsic chemical reactivity, metabolic transformation, and microbial modulation.
  • Application of a High Input, Rational Integration paradigm for evidence synthesis.

Main Results:

  • Curcumin acts as a network modulator influencing xenobiotic metabolism, transport, signaling, and host-microbiome interactions.
  • Bioactive metabolites contribute to its effects despite rapid clearance.
  • Clinical signals align with multifactorial dysregulation in metabolic, neurocognitive, and musculoskeletal disorders.

Conclusions:

  • Curcumin's pharmacology is pleiotropic and context-dependent, extending beyond traditional paradigms.
  • Discrepant clinical outcomes necessitate a unified approach to evidence interpretation.
  • The proposed framework aids in understanding complex bioactives in human studies.