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The Roles of SQSTM1/p62 in Selective Autophagy and Oncogenic Signaling
Young-Jun Kim1, Hwa-Hyeong Lee1, Tae Young Jung1
1College of Pharmacy, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Republic of Korea.
International Journal of Molecular Sciences
|March 14, 2026
Summary
Autophagy degrades cellular waste. This review explores how the p62 protein
Area of Science:
- Cell Biology
- Molecular Biology
- Oncology
Background:
- Autophagy is a cellular process for degrading damaged components.
- Three main types exist: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA).
- Sequestosome 1 (SQSTM1)/p62 acts as a selective autophagy receptor, linking various signaling pathways.
Purpose of the Study:
- To review the role of autophagy in cancer progression.
- To elucidate the mechanisms of autophagy, including p62-mediated pathways.
- To discuss the implications of impaired or excessive autophagy in cancer development.
Main Methods:
- Literature review of autophagy research.
- Analysis of signaling pathways involving p62, NF-κB, mTORC1, Keap1-NRF2.
- Examination of the role of p62 phase separation in autophagy.
Main Results:
- Autophagy, particularly macroautophagy mediated by p62, is crucial for cellular homeostasis.
- p62 integrates key signaling pathways (NF-κB, mTORC1, NRF2) to regulate selective autophagy.
- Dysregulation of p62-mediated autophagy is linked to cancer development and progression.
Conclusions:
- Autophagy and the p62 pathway are critical in cancer.
- Understanding these mechanisms offers potential therapeutic targets for cancer treatment.
- Further research into p62-mediated autophagy is warranted for cancer therapy.
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