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Related Experiment Video

Updated: Mar 15, 2026

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF

Published on: September 17, 2019

CSL305: A Dual Functional Therapeutic Antibody Targeting Complement C2 and FcRn.

Sandra Wymann¹, Rodrigo A V Morales², Wei Hong Toh²

¹CSL Biologics Research Centre, Swiss Institute for Translational and Entrepreneurial Medicine, 3010 Bern, Switzerland.

International Journal of Molecular Sciences

|March 14, 2026

Summary

This summary is machine-generated.

A novel dual-function monoclonal antibody, CSL305, inhibits both the complement system and the neonatal Fc receptor (FcRn). This antibody shows potential as a therapeutic candidate for autoimmune diseases by targeting key drivers of pathology.

Keywords:

FcRn antibody autoimmune diseases complement dual function immunotherapies

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Area of Science:

Immunology
Biochemistry
Drug Discovery

Background:

Autoimmune diseases involve complement and pathogenic antibodies.
Current therapies target complement or antibodies separately.

Purpose of the Study:

Develop a novel therapeutic agent targeting both complement and FcRn.
Characterize a dual-function monoclonal antibody (mAb), CSL305.

Main Methods:

Engineered CSL305 mAb to inhibit complement (C2, C3b deposition) and FcRn.
Utilized in vitro assays, 3D microvascular models, and crystal structure analysis.
Conducted pharmacokinetic/pharmacodynamic studies in cynomolgus monkeys.

Main Results:

CSL305 demonstrated in vitro inhibition of classical and lectin complement pathways and C3b deposition.
CSL305 blocked immunoglobulin G (IgG) recycling by antagonizing FcRn.
In vivo studies showed complement inhibition and reduced IgG levels post-administration.

Conclusions:

CSL305 is a potent dual-function mAb targeting complement and FcRn.
CSL305 represents a promising therapeutic candidate for autoimmune diseases.