New Insights into the Anti-Aging Mechanism of Collagen Peptides-Emphasis on Lysosomes and Mitochondria Function

Area of Science:

• Biochemistry
• Dermatology
• Cell Biology

Background:

• Skin aging is a growing concern with rising living standards.
• Collagen peptides are recognized for their anti-aging properties, but their mechanisms are unclear.
• Understanding these mechanisms is vital for developing effective anti-aging strategies.

Purpose of the Study:

• To elucidate the molecular mechanisms by which collagen peptides alleviate skin aging.
• To highlight the roles of lysosomes and mitochondria in collagen peptide-mediated skin anti-aging.
• To propose future research directions focusing on organelle function and collagen peptides.

Main Methods:

• This review synthesizes current research on collagen peptides and skin aging.
• It analyzes the multifaceted processes involved in collagen peptide action.
• It examines the potential roles of cellular organelles, particularly lysosomes and mitochondria.

Main Results:

• Collagen peptides combat skin aging by removing reactive oxygen species, reducing inflammation, and inhibiting extracellular matrix degradation and melanin deposition.
• They activate lysosomal and mitochondrial functions and promote extracellular matrix synthesis.
• Lysosomes and mitochondria are identified as key organelles mediating these effects.

Conclusions:

• Collagen peptide action in skin anti-aging is a complex, systematic process.
• Lysosomal and mitochondrial regulation by collagen peptides warrants further investigation.
• Future research should explore these pathways for precise skincare and targeted anti-aging therapies, moving beyond traditional signaling pathways like TGF-β/Smad.