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Updated: Mar 15, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Axially Chiral Compounds
Liying Cui1,2, Yin Zheng3
1School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China.
None:
Axially chiral compounds, indispensable in asymmetric catalysis, drug discovery, and materials science, have witnessed transformative advancements in synthesis through organocatalytic kinetic resolution (OKR) over the past decade. This review systematically dissects the latest achievements (2010-2025) in OKR, focusing on catalyst design, mechanistic insights, substrate diversification, and synthetic applications across C-C biaryl, C-N heterobiaryl, and olefinic axially chiral frameworks. By harnessing non-covalent interactions, OKR has emerged as a powerful strategy to overcome the challenges of low rotational barriers and limited stereocontrol, offering sustainable and enantioselective access to privileged chiral scaffolds. Furthermore, the current challenges and future prospects in this rapidly evolving field are assessed.
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