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Updated: Mar 15, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
Program interventions to build access to living donor transplantation.
Ingrid Woelfel1, Stephanie Yi2, Amit K Mathur1
1Mayo Clinic, Phoenix, Arizona.
Living donor transplantation offers superior outcomes for end-stage renal and liver disease patients. Implementing targeted strategies can significantly increase living donor transplants, improving patient care and transplant center efficiency.
Area of Science:
- Transplantation Medicine
- Organ Donation
- Nephrology
- Hepatology
Background:
- Living donor transplantation is the preferred treatment for end-stage renal disease (ESRD) and end-stage liver disease (ESLD).
- Benefits for recipients include enhanced graft survival and reduced waiting times compared to deceased donation.
- A strong living donor program benefits transplant centers through consistent case volumes and reduced reliance on policy changes.
Purpose of the Study:
- To outline actionable initiatives for transplant programs to increase living donor evaluations and surgeries.
- To optimize living donor transplantation within existing legal and policy frameworks.
- To enhance the capacity of transplant centers to serve patients with end-stage organ disease.
Main Methods:
- Review of best practices and peer-reviewed data for living donor transplantation.
- Identification of strategies to increase living donor volume.
- Analysis of current landscape and areas for innovation in living donation.
Main Results:
- Culturally competent education and outreach are key to increasing donor volume.
- Developing living donor champion programs and utilizing financial assistance programs are effective.
- Expanding paired donor exchange and adapting evidence-based selection criteria improve outcomes.
Conclusions:
- Understanding the current state of living donor transplantation is crucial.
- Exploring innovative approaches is essential for centers to meet patient needs.
- Continuous improvement in living donor programs ensures comprehensive care for end-stage organ disease patients.
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Published on: March 8, 2024
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