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Updated: Mar 16, 2026

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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
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Very Late Fracture of a First-Generation Drug-Eluting Stent.
Flora Tsakirian1, Dimitrios Afendoulis1, Sotirios Tsalamandris1
1Unit of Structural and Valvular Heart Diseases, First Department of Cardiology, National and Kapodestrian University of Athens, Hippokration General Hospital of Athens, Athens, Greece.
JACC. Case Reports
|March 14, 2026
Summary
First-generation drug-eluting stents can fracture decades after implantation, leading to very late stent failure. Management decisions for coronary stent fracture should prioritize patient symptoms and ischemia assessment over imaging alone.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Coronary stent fracture is an uncommon cause of very late stent failure, predominantly linked to first-generation drug-eluting stents.
- Mechanical failure of coronary stents can occur long after implantation.

