Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

70.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
70.1K
Polygenic Traits01:18

Polygenic Traits

11.3K
11.3K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

651
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
651
Bulimia Nervosa01:30

Bulimia Nervosa

939
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
939
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Co-creating a social science research agenda for Long Covid.

Frontiers in public health·2026
Same author

A systematic review and meta-analysis of the relative benefit of dual versus single oral hypoglycaemic therapy following diagnosis with type 2 diabetes (T2D).

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Improving social support among sports medicine practitioners: a call to action.

British journal of sports medicine·2026
Same author

Graves' Disease: Prospective Up to 10-Year Outcome for 100 Consecutive Individuals at a Single Centre.

Clinical endocrinology·2026
Same author

The insulin-like growth factor system and the progression of renal complications of type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

An Evaluation of Longitudinal Thyroid Hormone Levels Over the Years Before and After Patients Started on Levothyroxine.

Endocrinology, diabetes & metabolism·2026

Related Experiment Video

Updated: Mar 16, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World

Adrian Heald1,2, Yasitha Illangasekera3,4, Camila Marcelino Loureiro3

  • 1Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK.

Human Psychopharmacology
|March 14, 2026
PubMed
Summary

A new polygenic risk score (PRS) effectively predicts antipsychotic-induced weight gain (AIWG) in women with first episode psychosis. This genetic predisposition tool explains 59% of daily weight gain variance over time.

Keywords:
antipsychoticassociationgenepolygenic risk scorepsychosisweight gain

More Related Videos

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

5.3K
Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

5.3K
Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.4K

Area of Science:

  • Pharmacogenetics
  • Psychiatry
  • Genomics

Background:

  • Genetic factors significantly influence antipsychotic-induced weight gain (AIWG).
  • Polygenic risk scores (PRS) offer a method to quantify genetic predisposition to AIWG.
  • Understanding AIWG genetic underpinnings is crucial for personalized treatment in first-episode psychosis.

Purpose of the Study:

  • To develop and validate a PRS for predicting AIWG in individuals with first-episode psychosis.
  • To investigate the association between a novel PRS and weight changes over time.
  • To explore potential gender differences in the PRS's predictive capability for AIWG.

Main Methods:

  • A PRS was constructed using single nucleotide polymorphisms (SNPs) from six genes (HTR2C, MTHFR, ADRA2A, MC4R, LEPR, CNR1) associated with AIWG.
  • Additive and weighted PRS models were created, along with low/high genetic risk groups.
  • Regression analyses examined the association between PRS and weight gain per day (WGPD) and BMI percentage change.

Main Results:

  • The additive PRS significantly predicted AIWG in females (r² = 0.59, p < 0.05), but not in males.
  • High genetic risk groups exhibited greater WGPD (p = 0.018), with a significant PRS-gender interaction.
  • No significant association was found between the PRS models and BMI percentage change.

Conclusions:

  • A PRS incorporating specific SNPs can predict daily weight gain in women with first-episode psychosis, explaining a substantial portion of the variance.
  • Further validation in independent cohorts is necessary.
  • Prospective application feasibility of the PRS for AIWG management requires further investigation.