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Related Experiment Video

Updated: Mar 16, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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A Practical Phenotyping Framework for Male Lower Urinary Tract Symptoms Using Remote Multi-day Urinary Diagnostics.

Jeremy Watts1, Daniel Godelfer1, John Knoedler1

  • 1iO Urology Corporation, Knoxville, TN.

Urology
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Remote multi-day urinary diagnostics (RMUD) reveal diverse lower urinary tract symptom (LUTS) patterns in men. This phenotyping identifies mixed obstruction, overactivity, and nocturnal polyuria phenotypes, aiding personalized treatment.

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Area of Science:

  • Urology
  • Medical Diagnostics
  • Patient Phenotyping

Background:

  • Lower urinary tract symptoms (LUTS) affect many men.
  • Accurate phenotyping is crucial for effective LUTS management.
  • Current diagnostic methods may not fully capture symptom complexity.

Purpose of the Study:

  • To describe the distribution of Index Symptoms and Diagnostic Profiles in men with LUTS using Remote multi-day urinary diagnostics (RMUD).
  • To establish a phenotyping framework for LUTS based on RMUD data.

Main Methods:

  • Retrospective analysis of 1,047 RMUD studies in men with LUTS.
  • RMUD combined frequency-volume, uroflowmetry, and International Prostate Symptom Score (IPSS) data.
  • Six Index Symptoms and non-overlapping Diagnostic Profiles were defined.

Main Results:

  • 37.6% of men met obstructive criteria; 33.5% had overactivity, with 13.9% primary overactivity.
  • Nocturia (>2/night) affected 67.3%, and nocturnal polyuria (NP) affected 46.8%.
  • 21 distinct Diagnostic Profiles emerged, often showing mixed storage-voiding-NP phenotypes.

Conclusions:

  • RMUD-based phenotyping reveals significant heterogeneity in LUTS presentation among men.
  • Identified patterns include obstruction, overactivity, and nocturnal polyuria.
  • This framework supports precise patient counseling, treatment selection, and further evaluation.