Widespread distribution of variant forms of carbonic anhydrase in Australian aboriginals
Abstract:
Three distinctive genes which control variants of carbonic anhydrase (CA) have been detected in tests on nearly 3000 Aboriginals from various parts of Australia. Two of these genes affect the products of the CA1 locus, the other affects the products of the CA2 locus. In some populations of Aboriginals, more than 10% of persons have a variant carbonic anhydrase. It is suggested that such an unusual frequency of CA variants may be an evolutionary response to metabolic stress connected either with low zinc concentrations in the diet or with the altered needs of ion regulation in an arid environment.
More Related Videos
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
09:20Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants
Published on: October 18, 2022
Related Concept Videos
Genetic Lingo
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Single Nucleotide Polymorphisms-SNPs
Aquaporins
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
