Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tracheal fluid in fetal lambs: spontaneous decrease prior to birth.

J A Kitterman, P L Ballard, J A Clements

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Constraints to counting bioluminescence producing cells by a commonly used transgene promoter and its implications for experimental design.

    Scientific reports·2019
    Same author

    The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform.

    Scientific reports·2018
    Same author

    A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo.

    Journal of tissue engineering and regenerative medicine·2017
    Same author

    Determining Protease Substrates Within a Complex Protein Background Using the PROtein TOpography and Migration Analysis Platform (PROTOMAP).

    Methods in molecular biology (Clifton, N.J.)·2017
    Same author

    Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

    British journal of cancer·2015
    Same author

    The kallikrein-related peptidase family: Dysregulation and functions during cancer progression.

    Biochimie·2015

    Tracheal fluid production in fetal lambs decreases before labor, independent of atropine or vagosympathetic trunk section. This reduction may be linked to elevated cortisol levels preceding birth.

    Area of Science:

    • Reproductive Physiology
    • Fetal Development
    • Endocrinology

    Background:

    • Tracheal fluid (TF) production is crucial for fetal lung development and function.
    • Understanding factors influencing TF production is vital for managing preterm birth complications.

    Purpose of the Study:

    • To investigate the changes in tracheal fluid production in fetal lambs nearing term.
    • To determine the influence of autonomic nervous system modulation and cortisol on TF production.

    Main Methods:

    • TF production was measured in 14 fetal lambs using a cannula diversion technique.
    • Experimental groups included controls, fetuses treated with atropine, and those with vagosympathetic trunk section.
    • Plasma cortisol concentrations and blood gas tensions were analyzed.

    Related Experiment Videos

    Main Results:

    • TF production significantly decreased in the days preceding spontaneous labor in most fetuses.
    • This decrease was not altered by atropine administration or vagosympathetic trunk section.
    • TF production showed an inverse correlation with plasma cortisol concentrations measured 48 hours prior.

    Conclusions:

    • Tracheal fluid production declines before spontaneous term or preterm labor in fetal lambs.
    • Autonomic pathways (atropine, vagosympathetic trunk) do not appear to regulate this pre-labor decrease.
    • Increased cortisol secretion is a potential mediator for the observed reduction in TF production.