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Updated: Mar 16, 2026

Measuring RAN Peptide Toxicity in C. elegans
Published on: April 30, 2020
Plant-based models of neurodegenerative CAG repeat expansion diseases
Mythili Saravanan1, Farooqahmed S Kittur1, Jiahua Xie1
1Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
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Expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats causes Huntington's disease and other neurodegenerative disorders, yet no disease-modifying treatments exist. Plant-based CAG models expressing mutant huntingtin protein provide novel insights into expanded CAG-induced toxicity, complementing traditional systems for studying neurodegeneration and therapeutic discovery, and may offer unique opportunities for advancing plant biology research.

