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Effects of Transradial Catheterisation on Radial Artery Bypass Graft Patency: A Systematic Review and Meta-Analysis
Yantong Wang1, Varun Sharma2, Tony Vu3
1School of Translational Medicine, Monash University, Melbourne, Vic, Australia; Department of Surgery, Monash University, Melbourne, Vic, Australia.
Insights
Prior transradial catheterisation reduces radial artery bypass graft patency. Surgeons should carefully consider using previously catheterised radial arteries for coronary artery bypass grafting due to increased graft failure risk.
Area of Science:
- Cardiovascular Surgery
- Vascular Grafting
- Interventional Cardiology
Background:
- Transradial catheterisation is standard for coronary angiography.
- Radial artery (RA) is a common choice for coronary artery bypass grafting (CABG).
- Uncertainty exists regarding the suitability of previously catheterised RA (CRA) as a CABG conduit.
Purpose of the Study:
- To systematically review and meta-analyze the patency of previously catheterised radial artery (CRA) bypass grafts compared to non-catheterised radial artery (NCRA) grafts.
Main Methods:
- Systematic search of MEDLINE, Embase, and Scopus for comparative studies.
- Inclusion of four observational studies (400 patients).
- Random-effects models for pooled effect sizes, heterogeneity assessed by I²; small-study effects examined via funnel plot/Egger's test.
Main Results:
- CRA graft patency (73.2%) was lower than NCRA (83.9%).
- Pooled odds of graft failure were significantly higher for CRA (OR 1.82; 95% CI 1.26-2.61; p=0.001).
- Mean follow-up was approximately 2 years; no significant small-study biases were detected.
Conclusions:
- Prior transradial catheterisation is linked to reduced radial artery bypass graft patency.
- Caution is advised when selecting CRA for critical targets in CABG.
- Further prospective studies are needed to identify risk modifiers.
Background:
Transradial catheterisation is the default approach of coronary angiography, and the radial artery (RA) is a popular conduit choice for coronary artery bypass grafting (CABG). Whether a previously catheterised RA (CRA) remains an optimal bypass conduit for CABG is uncertain. This systematic review and meta-analysis sought to evaluate the previous CRA bypass graft patency.
Method:
A systematic search is conducted in MEDLINE, Embase, and Scopus for comparative studies of CRA versus non-CRA (NCRA) grafts. The primary outcome of this study was RA graft patency. Random-effects models generated pooled effect sizes with heterogeneity assessed by I2; small-study effects were examined with funnel plot/Egger's test, and influence analyses were performed in the meta-analysis.
Results:
Of the 1,661 studies screened, four observational studies of 400 patients (175 CRA and 379 NCRA grafts) were included in the analysis. Across the included studies, the mean time from catheterisation to CABG was 27.4±16.0 days; the mean follow-up imaging was conducted at 2.06±1.88 years. CRA graft patency was lower than NCRA (73.2% vs 83.9%), and the pooled odds of graft failure were higher with CRA (odds ratio 1.82; 95% confidence interval 1.26-2.61; p=0.001; I2=33%). There were no significant small-study biases detected on planned assessments.
Conclusions:
Prior transradial catheterisation is associated with reduced patency of RA bypass grafts. Surgeons should exercise caution when selecting CRA for critical targets, and prospective controlled data are needed to define patient and procedural modifiers of risk.
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