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Fibroblast-associated CTHRC1 as a key indicator of recurrence risk in prostate cancer

Yuan Ma1, Gaoteng Lin2, Keruo Wang3

  • 1Department of Urology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100000, China.

World Journal of Surgical Oncology
|March 15, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CTHRC1Immune infiltrationProstate cancerSingle-cell RNA-seqTumor microenvironment

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Introduction to Fibroblasts01:09

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

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