Related Experiment Video
Updated: Mar 16, 2026
07:10
Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
5.1K
Drug-Induced acute Pancreatitis: A Real-World Pharmacovigilance Study Using the Tunisian Databases.
Hiba Ben Hassine1, Faiez Boughanmi1, Abir Lefi2
1Department of Visceral Surgery, Fattouma Bourguiba University Hospital, Faculty of Medicine of Monastir, University of Monastir, 5000 Monastir, Tunisia.
La Tunisie Medicale
|March 15, 2026
Summary
Drug-induced acute pancreatitis (AP) is rare but recognized. This study identified common symptoms and implicated drugs like captopril, atorvastatin, and azathioprine, with most patients experiencing favorable outcomes.
Area of Science:
- Gastroenterology
- Pharmacology
- Clinical Medicine
Background:
- Acute pancreatitis (AP) is an inflammatory pancreatic condition, often linked to gallstones or alcohol.
- Drug-induced AP is an emerging etiology with limited published data.
Purpose of the Study:
- To investigate the epidemiological, clinical, radiological, and management features of drug-induced AP.
- To analyze data from Tunisian databases for drug-associated pancreatitis cases.
Main Methods:
- A retrospective analysis of 13 drug-induced AP cases among 1580 AP patients over five years.
- Data collected included patient demographics, clinical presentation, diagnostic methods, treatments, and outcomes.
Main Results:
- The study identified 13 cases of drug-induced AP, with a mean patient age of 55.62 years and 77% male predominance.
- Common symptoms were epigastric pain (100%) and elevated lipase (92.3%).
- Key implicated drugs included captopril (38.5%), atorvastatin (23.1%), azathioprine (23.1%), metformin, and olanzapine.
Conclusions:
- Drug-induced pancreatitis is a distinct clinical entity necessitating multidisciplinary care.
- Prompt identification and reporting of suspected drug-induced AP are crucial for enhancing pharmacovigilance.
Related Concept Videos
01:19Pharmacovigilance
1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K
01:30Acute Pancreatitis II: Clinical Manifestations and Management
1.0K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.0K
01:27Acute Pancreatitis I: Introduction
1.4K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.4K
01:29Chronic Pancreatitis II: Collaborative Care
456
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
456
01:27Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
56
Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
56
01:16Drug toxicity: Idiosyncratic Reactions
114
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
114