Related Experiment Video
Updated: Jul 22, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
11.0K
Bullous Systemic Lupus Erythematosus in a Southeast Asian Cohort: High Systemic Association Driving Systemic Therapy
Chuda Rujitharanawong1, Kanokvalai Kulthanan1, Papapit Tuchinda1
1Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University.
Asian Pacific Journal of Allergy and Immunology
|March 15, 2026
Summary
Bullous systemic lupus erythematosus (BSLE) is a rare skin condition linked to lupus erythematosus (SLE). This study found BSLE often indicates significant internal organ involvement, requiring aggressive treatment.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Background:
- Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering disease associated with systemic lupus erythematosus (SLE).
- Limited data exists on BSLE, especially in Southeast Asian populations.
Purpose of the Study:
- To evaluate the clinical, histopathologic, immunofluorescence, and serologic features of BSLE.
- To review existing literature on BSLE.
Main Methods:
- Retrospective review of BSLE patients diagnosed at Siriraj Hospital (2003-2024).
- Analysis included clinical data, histology, immunofluorescence, and serology.
Main Results:
- BSLE occurred in 0.13% of cutaneous lupus erythematosus patients (12/9055).
- Most patients (75%) presented with BSLE at SLE diagnosis; 75% had systemic involvement (kidneys, hematologic).
- Immunofluorescence showed IgG and C3 deposition; treatment often required systemic corticosteroids and immunosuppressants.
Conclusions:
- BSLE, though uncommon, is a significant cutaneous manifestation of SLE.
- BSLE strongly correlates with systemic disease, particularly renal and hematologic complications.
- Treatment typically necessitates immunosuppressive agents due to disease severity.
