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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

Type 2 high asthma phenotype in children: A multidimensional clustering analysis.

Soyoung Bae¹, Hyejin Lee¹

¹Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Asian Pacific Journal of Allergy and Immunology

|March 15, 2026

Summary

This study identified three childhood asthma phenotypes using cluster analysis. A T2-high asthma cluster showed distinct immunological and clinical features, including high airway hyperresponsiveness and reduced lung function.

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Murine Model of Allergen Induced Asthma

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Published on: May 14, 2012

Area of Science:

Pediatric Allergy and Immunology
Respiratory Medicine
Computational Biology

Background:

Childhood asthma is a complex disease with poorly defined phenotypes.
Understanding these phenotypes is crucial for effective management.

Purpose of the Study:

To classify childhood asthma phenotypes using unsupervised clustering.
To analyze clinical characteristics and outcomes of identified phenotypes based on type 2 (T2) biomarkers.

Main Methods:

Retrospective analysis of 614 pediatric asthma patients.
Hierarchical clustering using age, absolute eosinophil count (AEC), eosinophil cationic protein (ECP), and total immunoglobulin E (IgE).
Comparison of clinical characteristics and 2-year outcomes across clusters, with age adjustment.

Main Results:

Three distinct asthma clusters were identified.
A T2-high cluster (Cluster 2) showed elevated T2 biomarkers, airway hyperresponsiveness, and reduced lung function.
Other clusters presented with high exacerbation rates (Cluster 1) or lower burden (Cluster 3), with varying T2 levels.

Conclusions:

A distinct T2-high phenotype in school-aged children with asthma was identified.
This phenotype is characterized by specific immunological profiles and clinical outcomes, including airway hyperresponsiveness and decreased lung function.