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Relationship of chemerin with nutritional status and appetitive traits in early childhood: a cross-sectional study

Aylin Yüksel Ülker1,2, İlker Tolga Özgen3,4, Yaşar Cesur3

  • 1Division of Pediatrics Endocrinology, Bezmialem Vakıf University Medical Faculty, Istanbul, Turkey. aylinyukselulker@gmail.com.

European Journal of Pediatrics
|March 15, 2026
PubMed

Insights

Serum chemerin levels are lower in children with appetite-related undernutrition. These findings suggest a link between chemerin, nutritional status, and appetite traits in early childhood.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Adipokine Research

Background:

  • Chemerin is an adipokine involved in energy metabolism, adipogenesis, and inflammation.
  • Elevated chemerin is linked to obesity and metabolic disorders, but its role in childhood appetite is understudied.

Purpose of the Study:

  • To investigate the relationship between serum chemerin levels, nutritional status, and appetitive traits in early childhood.
  • To compare chemerin levels in children with and without appetite-related undernutrition.

Main Methods:

  • Cross-sectional study of 85 children aged 2-9 years.
  • Appetitive traits assessed using the Child Eating Behavior Questionnaire (CEBQ).
  • Serum chemerin levels measured and correlated with anthropometric and biochemical parameters.

Main Results:

  • Children with appetite-related undernutrition exhibited significantly lower serum chemerin levels compared to those with normal appetite.
  • Chemerin levels positively correlated with food approach traits and inversely with food avoidance traits.
  • Positive associations found between chemerin and LDL cholesterol, total cholesterol, albumin, and calcium.

Conclusions:

  • Lower serum chemerin levels are associated with appetite-related undernutrition in children.
  • Chemerin may play a role in regulating nutritional status and appetite in early childhood.

Keywords:
AdipokineAppetiteChemerinChildhoodNutritional status

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