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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Association between bedtime snacking and subclinical hypothyroidism.

Yuji Shimizu^1,2, Nagisa Sasaki², Asuka Oyama²

¹Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences.

Environmental Health and Preventive Medicine

|March 15, 2026

Summary

Bedtime snacking is linked to subclinical hypothyroidism (SCH), possibly by increasing the need for endothelial repair. This habit may indicate early thyroid and endothelial dysfunction.

Keywords:

Bedtime snacking Endothelial repair Euthyroid population Subclinical hypothyroidism

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Area of Science:

Endocrinology
Nephrology
Cardiovascular Science

Background:

Thyroid hormones are crucial for endothelial repair.
Bedtime snacking is associated with increased risk of chronic kidney disease (CKD).
Endothelial dysfunction is a key feature of CKD, suggesting a link between snacking, endothelial health, and thyroid function.

Purpose of the Study:

To investigate the association between bedtime snacking and subclinical hypothyroidism (SCH).

Main Methods:

Cross-sectional study of 1,478 Japanese adults aged 40-69 with normal thyroid function.
SCH defined as elevated TSH (>4.01 µIU/mL).
Bedtime snacking assessed by self-report (≥3 times/week within 2 hours of bedtime).

Main Results:

263 participants reported bedtime snacking; 81 had SCH.
Bedtime snacking was significantly associated with SCH (OR 1.77; 95% CI 1.05-2.99).
Association remained significant after adjusting for confounders including diet, metabolic, and cardiovascular risk factors.

Conclusions:

Bedtime snacking is positively associated with SCH.
This link may stem from increased physiological demand for endothelial repair.
Findings suggest bedtime snacking could be an early marker for endothelial and thyroid dysfunction.