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Updated: Mar 17, 2026
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
Low-density lipoprotein cholesterol thresholds in patients with heart failure of ischemic vs nonischemic etiology
Luis Eduardo Echeverria1, Clara Saldarriaga2, Alex Rivera-Toquica3
1Cardiology Service, Fundación Cardiovascular de Colombia, FCV, Floridablanca, Santander, Colombia (Echeverria).
Insights
Patients with ischemic heart failure (HF) are more likely to achieve low-density lipoprotein cholesterol (LDL-C) goals compared to nonischemic HF patients. This highlights the need for tailored HF management strategies based on etiology.
Area of Science:
- Cardiology
- Heart Failure Research
- Lipid Management
Background:
- Controlling lipid levels is crucial for preventing secondary cardiovascular events.
- Limited in-depth data exists on coronary artery disease patient characteristics relative to low-density lipoprotein cholesterol (LDL-C) levels.
Purpose of the Study:
- To characterize heart failure (HF) patients by etiology (ischemic vs. nonischemic) based on LDL-C levels.
- To assess LDL-C goal attainment using <70 mg/dL and <100 mg/dL thresholds.
Main Methods:
- Analysis of data from the third phase of the Colombian Registry of Heart Failure (RECOLFACA).
- Collection of sociodemographic, clinical, and laboratory data at baseline.
- Logistic regression modeling for LDL-C goal achievement analysis.
Main Results:
- 1124 patients included: 554 ischemic HF, 570 nonischemic HF.
- Ischemic HF patients showed a higher probability of achieving LDL-C <70 mg/dL (OR=1.62) and <100 mg/dL (OR=1.43) goals.
- Rosuvastatin use was higher in ischemic HF patients reaching LDL-C <70 mg/dL goal (40.4%) compared to nonischemic HF (19.6%).
Conclusions:
- Distinct clinical profiles and treatment patterns exist between ischemic and nonischemic HF patients.
- LDL-C goal attainment varies significantly based on HF etiology.
- Tailored management strategies are essential, considering the specific etiology of heart failure.
Background:
Keeping lipid levels under control is key to preventing secondary cardiovascular events; however, few studies have detailed in depth the characteristics of patients with coronary artery disease according to low-density lipoprotein cholesterol (LDL-C) levels.
Objective:
To characterize patients with heart failure (HF) of ischemic or nonischemic etiology according to their LDL-C levels and considering the thresholds of <70 mg/dL and <100 mg/dL for LDL-C goals.
Methods:
We present the results from the third phase of the Colombian Registry of Heart Failure (RECOLFACA). Sociodemographic, clinical, and laboratory data were collected at baseline. For the LDL-C goal analysis, we conducted a logistic regression model.
Results:
We included 1124 patients, 554 with ischemic and 570 with nonischemic HF. The cohort included 379 women (33.7%) and 745 men (66.3%). There was a difference in the prescription of statins observed for both ischemic and nonischemic HF groups. Patients with ischemic HF had a 62% probability of being at the LDL-C <70 mg/dL goal (odds ratio [OR] = 1.62) and a 43% probability of being at the <100 mg/dL goal (OR = 1.43). Rosuvastatin was more used by patients with ischemic HF in the <70 mg/dL LDL-C goal group in comparison to those on the same goal group but with nonischemic HF (40.4% vs 19.6%, respectively). Similar results were reported for the <100 mg/dL LDL-C goal.
Conclusion:
Our findings provide insights into distinct clinical profiles, treatment patterns, and LDL goal attainment in patients with ischemic and nonischemic HF, emphasizing the need for tailored management strategies based on HF etiology.
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