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Updated: Mar 17, 2026

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
Published on: July 17, 2021
oDual-MRF: An Optimized Dual-Alternating MR Fingerprinting Sequence
Shizhuo Li1, Bo Zhao2,3, Pengcheng Xu1
1College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
Purpose:
To improve the quantitative accuracy of mapping in magnetic resonance fingerprinting by introducing the Dual-MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization.
Methods:
The PSIF module was incorporated into the MRF sequence, resulting in the Dual-MRF sequence with alternating signals. Furthermore, the oDual-MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer-Rao Bound. The performance of FISP-MRF, Dual-MRF, and oDual-MRF was evaluated through simulations, phantom experiments, and in vivo studies.
Results:
Dual-MRF achieved higher quantification accuracy compared to conventional FISP-MRF while maintaining accuracy. oDual-MRF further improved accuracy without compromising map quality.
Conclusion:
CRB-based optimization of Dual-MRF enhances quantification while preserving accuracy, providing a promising framework for reliable multiparametric MRF.
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