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Related Experiment Video

Updated: Mar 17, 2026

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The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression.

Asimina I Karampela1, Maralyn Druce1

  • 1Centre for Endocrinology, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Clinical Endocrinology
|March 15, 2026
PubMed
Summary

Polycystic ovary syndrome (PCOS) is linked to depression through biological and psychosocial factors. Understanding these complex connections is crucial for effective patient support and risk stratification.

Keywords:
body imagedepressionhyperandrogenisminsulin resistanceobesitypolycystic ovary syndromepsychological distress

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Reproductive Health

Background:

  • Polycystic ovary syndrome (PCOS) is a common endocrine disorder.
  • PCOS frequently co-occurs with psychological comorbidities, notably depression.

Purpose of the Study:

  • To review current research on the contributors and mechanisms linking PCOS and depression.
  • To synthesize findings on the bidirectional relationship between PCOS and depression.

Main Methods:

  • Systematic literature search of the PubMed database.
  • Utilized 'snowballing' technique for study identification.
  • Assessed study quality using the GRADE framework; depression was measured via validated questionnaires.

Main Results:

  • The PCOS-depression link is bidirectional and multifactorial.
  • Biological factors include hyperandrogenism, metabolic dysregulation, inflammation, gut microbiome, and genetics.
  • Psychosocial factors encompass illness perception (obesity, acne, hirsutism), menstruation, infertility, sexual dysfunction, and eating disorders.

Conclusions:

  • No single unifying mechanism explains the PCOS-depression relationship due to complex pathophysiology.
  • Emphasizes the need for mental health risk assessment in PCOS patients.
  • Highlights the importance of addressing contributing factors and providing comprehensive support.