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Kounis Syndrome: A Systematic Review and Meta-analysis
Junior David Kalambay1, Mohammad Tashli1, Mohammad Zaman2
1Internal Medicine, MountainView Regional Medical Center, Las Cruces, New Mexico.
The American Journal of Cardiology
|March 16, 2026
Summary
Kounis syndrome, an allergic acute coronary syndrome, shows trigger-specific age patterns and a consistent male predominance. Most patients recover, indicating generally favorable outcomes despite limited data.
Area of Science:
- Cardiology
- Allergy and Immunology
- Clinical Research Methodology
Background:
- Kounis syndrome (KS) is an allergic acute coronary syndrome.
- Existing evidence is limited to case reports and small case series, necessitating further characterization.
Conclusions:
- This meta-analysis offers a quantitative synthesis of Kounis syndrome characteristics.
- Findings highlight trigger-specific demographics and generally favorable outcomes.
- Reporting variability limits definitive conclusions, underscoring the need for standardized data collection.
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