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Design, synthesis and antitumor activity of celastrol thiazole derivatives with enhanced covalent binding capacity

Siqi Zhang1, Maoshan Zhang1, Bing Zhang1

  • 1State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.

Bioorganic & Medicinal Chemistry Letters
|March 16, 2026
PubMed

Keywords:
Antitumor activityApoptosisCelastrolCell cycleCovalent binding

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