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Research Progress of Metabolic Reprogramming in Childhood Acute Leukemia.

Yuzhi Yan1,2, Fangfang Zhong1,2

  • 1Pediatric Department of Urology and Immunology, Children's Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Pediatric Blood & Cancer
|March 16, 2026
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Summary

Pediatric leukemia cells reprogram metabolism for survival. Targeting these metabolic changes offers new strategies to fight acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in children.

Keywords:
cellular metabolismchildhood acute leukemiametabolic reprogrammingrelapsetargeted therapy

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Area of Science:

  • Oncology
  • Biochemistry
  • Pediatric Hematology/Oncology

Background:

  • Pediatric acute leukemia (AL), including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), is a major childhood cancer.
  • Metabolic reprogramming is a key factor in AL's development, progression, and treatment resistance.

Purpose of the Study:

  • To review recent advances in understanding metabolic reprogramming in pediatric AL subtypes (ALL/AML).
  • To synthesize targeted intervention strategies based on these metabolic alterations.

Main Methods:

  • Comprehensive literature review of studies on pediatric AL metabolism.
  • Analysis of subtype-specific metabolic pathways and molecular abnormalities.

Main Results:

  • Leukemic cells alter metabolism to support rapid proliferation.
  • Distinct metabolic profiles exist for ALL and AML subtypes.
  • Targeting key metabolic pathways shows promise in eradicating leukemic cells.

Conclusions:

  • Understanding metabolic reprogramming is crucial for overcoming drug resistance and reducing relapse in pediatric AL.
  • Targeting metabolic vulnerabilities offers a promising avenue for novel therapeutic strategies.