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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Updated: May 12, 2026

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Nanocascade Engineering Workshop for Synergistic Microenvironment Reprogramming and EpSC Revitalization in Precise

Rong Shi^1,2, Chao Hu^1,3, Wei Zhang¹

¹Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma and Chemical Poisoning, Army Medical University, Chongqing, China.

Advanced Materials (Deerfield Beach, Fla.)

|March 16, 2026

Summary

This summary is machine-generated.

This study introduces a novel nanotherapy that reshapes the inflammatory microenvironment and activates epidermal stem cells (EpSCs) to accelerate chronic wound healing, particularly in diabetic models.

Keywords:

diabetic wounds epidermal stem cells gene delivery microenvironment reprogramming nanozyme

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Last Updated: May 12, 2026

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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Chronic wounds, especially diabetic ones, exhibit impaired closure due to chronic inflammation and reduced stem cell function.
The inflammatory microenvironment critically hinders epidermal stem cell (EpSC) proliferation and differentiation, delaying wound healing.
Current treatments often face reduced efficacy in the pathological milieu of chronic wounds.

Purpose of the Study:

To develop a nanotherapy that simultaneously modulates the inflammatory microenvironment and enhances EpSC function for accelerated chronic wound closure.
To investigate the efficacy of a core-shell nanostructure in promoting regeneration and combating infection in chronic wound models.

Main Methods:

Designed a core-shell nanostructure (Cu5.4O@LL-37/pDNA) comprising a Cu5.4O nanozyme core and an LL-37/pDNA shell.
The Cu5.4O core scavenges reactive oxygen species and modulates the inflammatory milieu.
The LL-37/pDNA shell enhances gene delivery and provides antibacterial properties.

Main Results:

The nanotherapy effectively reshaped the inflammatory microenvironment, creating a regenerative niche.
It promoted EpSC proliferation and differentiation by enhancing gene delivery and sustained P311 expression.
Accelerated re-epithelialization and wound closure were observed in both diabetic and infection models.

Conclusions:

The developed nanotherapy offers a dual-action approach to chronic wound management by addressing both the microenvironment and cellular dysfunction.
This strategy shows significant potential for achieving durable and effective healing in challenging chronic wounds.
The Cu5.4O@LL-37/pDNA system represents a novel therapeutic avenue for regenerative medicine in wound care.