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Updated: Mar 17, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Cobalt-Catalyzed Asymmetric Hydroboration of Alkenyl Acetals
Liu Yang1, Jie Li2, Wanxiang Zhao1
1State Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China.
Abstract:
Transition-metal-catalyzed asymmetric hydroboration of alkenes has emerged as a powerful tool for constructing chiral boronates, yet asymmetric hydroboration of functionalized alkenes remains underdeveloped. Herein, we report a cobalt-catalyzed asymmetric hydroboration of alkenyl acetals, enabling efficient access to enantioenriched boryl acetals (up to 99% ee). The reaction proceeds efficiently on a gram scale with only 1 mol % catalyst and enables diverse downstream functionalizations, highlighting the synthetic potential of the resulting boryl acetals.
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