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Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity
Zedong Zhang1,2, Guangchun Song3, Ji Shen1,2
1School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
Journal of the American Chemical Society
|March 16, 2026
Summary
Researchers developed a flexible single-atom nanozyme (FSAzyme) with adaptable active sites. This breakthrough offers enzyme-like flexibility and versatile sensing capabilities, overcoming limitations of traditional inorganic nanozymes.
Area of Science:
- Materials Science
- Nanotechnology
- Biochemistry
Background:
- Inorganic nanozymes possess rigid active-center structures, limiting their functional adaptability compared to natural enzymes.
- Developing nanozymes with flexible and adaptive properties is crucial for advancing their applications.
Purpose of the Study:
- To design and synthesize a flexible single-atom nanozyme (FSAzyme) with adaptive capabilities.
- To demonstrate the enzyme-mimicking activities and versatile sensing functions of the FSAzyme.
Main Methods:
- Regulation of Gallium (Ga) coordination to create a flexible active site.
- Characterization of the dynamically reconstructing Ga-N3S site.
- Evaluation of enzyme-mimicking activities and sensing performance.
Main Results:
- A novel flexible single-atom nanozyme (FSAzyme) was successfully developed.
- The dynamically reconstructing Ga-N3S site demonstrated self-adaptive electronic modulation.
- The FSAzyme exhibited multiple enzyme-mimicking activities and versatile sensing functions.
Conclusions:
- The developed FSAzyme overcomes the rigidity limitations of traditional inorganic nanozymes.
- This work presents a general design strategy for creating enzyme-like adaptive single-atom nanozymes.
- The findings open new avenues for advanced nanozyme design and applications in sensing.
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