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Injection-site calcified granuloma: A silent complication of repeated intramuscular injections

R G Sawant1, A S Lodha

  • 1Department of Pathology, Symbiosis Medical College for Women and Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed University), Pune, Maharashtra, India.

Journal of Postgraduate Medicine
|March 16, 2026
PubMed
Abstract

No abstract available in PubMed .

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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