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Related Experiment Video

Updated: Mar 17, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Precautions for polygenic embryo selection: prohibition or cautious use.

Tetsuya Ishii1

  • 1Office of Health and Safety, Hokkaido University, Sapporo City, Japan.

Frontiers in Reproductive Health
|March 16, 2026
PubMed
Summary

Polygenic embryo selection, using genetic scores to choose embryos, is expanding despite clinical uncertainty. This practice risks harms like false expectations and child objectification, necessitating policy responses.

Keywords:
embryo selectionethicspolicypolygenic scoreprecautionpreimplantation genetic testingregulationtrait prediction

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Area of Science:

  • Reproductive genetics
  • Bioethics
  • Genetic counseling

Background:

  • Polygenic scores (PGS) predict complex traits from genetic variations.
  • Preimplantation genetic testing (PGT) for PGS is emerging for embryo selection.
  • Ethical concerns surround PGT for polygenic scores.

Purpose of the Study:

  • Analyze implications of polygenic embryo selection.
  • Propose policy responses to emerging PGT for PGS practices.

Main Methods:

  • Review of current literature on polygenic scores and PGT.
  • Ethical analysis of embryo selection based on polygenic scores.
  • Policy analysis and recommendations.

Main Results:

  • Clinical uncertainty persists regarding PGS accuracy for complex traits.
  • Parental desire for perceived 'healthy' or 'intelligent' offspring drives use.
  • Offspring outcomes may not meet expectations due to environmental and genetic factors.
  • Practices risk socio-ethical harms: false expectations, child objectification, trait stigma.

Conclusions:

  • Professional societies and policymakers must address risks of polygenic embryo selection.
  • Warning parents about limitations and ethical concerns is crucial.
  • Prohibition of polygenic embryo selection may be warranted, with potential exceptions for severe diseases.