Linoleic Acid Supplementation Attenuates Inflammation and Redox Imbalance During Aging in Wistar Rats

Area of Science:

• Gerontology
• Biochemistry
• Molecular Biology

Background:

• Aging is characterized by the accumulation of cellular and molecular damage.
• Oxidative stress and inflammation are key contributors to age-related functional decline.
• Understanding interventions that mitigate these aging hallmarks is crucial.

Purpose of the Study:

• To investigate the impact of Linoleic acid (LA) supplementation on oxidative stress and inflammation biomarkers.
• To compare these effects in young and old rats.

Main Methods:

• Young and old male rats were divided into control and LA-treated groups.
• LA was administered orally at 5 mg/kg body weight for 28 days.
• Key biomarkers of oxidative stress (ROS, MDA, AOPPs, PCO) and antioxidant status (FRAP, SOD, CAT, GSH, PMRS) were measured.

Main Results:

• Old rats exhibited significantly higher levels of oxidative stress and inflammatory markers compared to young rats.
• LA treatment in old rats led to a significant increase in antioxidant biomarkers (FRAP, PMRS, GSH, SOD, CAT).
• LA treatment significantly decreased oxidative stress (ROS, MDA, PCO, AOPP) and inflammatory markers in old rats.

Conclusions:

• Linoleic acid (LA) supplementation demonstrates a protective effect against oxidative stress and inflammation in aging rats.
• LA may play a role in maintaining redox homeostasis and reducing inflammatory burden in the blood.
• These findings support the potential of LA as a therapeutic agent to counteract age-related oxidative damage.