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A Case of Grade 2 Radiation‑Induced Osteosarcoma.
Flore Brachotte1, Matthieu Wendling2
1Medicine Resident in Radiology (5th year), CHU Liège Sart‑Tilman, Uliège, Belgium.
Journal of the Belgian Society of Radiology
|March 16, 2026
Summary
Radiation-induced osteosarcoma is a rare but serious complication that can occur years after radiation therapy. This teaching point emphasizes considering this possibility in painful, ossifying masses within previously irradiated areas.
Area of Science:
- Oncology
- Orthopedic Oncology
- Radiation Oncology
Background:
- Osteosarcoma is a primary bone cancer.
- Radiation therapy is a common cancer treatment.
- Secondary malignancies can arise after radiation exposure.
Purpose of the Study:
- To highlight the importance of considering radiation-induced osteosarcoma.
- To inform clinicians about a potential complication of radiation therapy.
Main Methods:
- Case review
- Literature review
Main Results:
- Radiation-induced osteosarcoma can occur years after treatment.
- Painful, ossifying masses in irradiated areas are suspicious.
Conclusions:
- Clinicians should maintain a high index of suspicion for radiation-induced osteosarcoma.
- Early diagnosis and treatment are crucial for favorable outcomes.
Keywords:
magnetic resonance imagingosteosarcomapositron emission tomography computed tomographyradiation‑induced neoplasmssoft tissue neoplasms
