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Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

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The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
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In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Integrating Molecular Modeling and Nanoemulsion Characterization for Ibuprofen.

Antônio S N Aguiar1,2, Luana A F Afiune1,3, Vitória A M Silva1

  • 1Laboratório de Novos Materiais, Universidade Evangélica de Goiás, Anápolis 75083-515, Goiás, Brazil.

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Summary
This summary is machine-generated.

This study explored ibuprofen's (IBU) solid-state properties and their impact on drug delivery. Nanoemulsions (NE-IBU) showed superior stability and pharmaceutical potential for hydrophobic drugs compared to standard emulsions (EM-IBU).

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Ibuprofen (IBU), a common NSAID, faces challenges with low aqueous solubility and polymorphism, affecting its bioavailability.
  • Understanding IBU's solid-state properties is crucial for optimizing drug delivery systems.

Purpose of the Study:

  • To investigate the structural, electronic, and supramolecular properties of two IBU polymorphic forms.
  • To assess how these properties influence the development and performance of emulsion-based drug delivery systems.

Main Methods:

  • Solid-state characterization using Hirshfeld surface analysis, quantum theory of atoms in molecules, and density functional theory.
  • Preparation and characterization of ibuprofen emulsion (EM-IBU) and nanoemulsion (NE-IBU) formulations.
  • Physicochemical characterization including droplet size, PDI, zeta potential, density, and drug content via mass spectrometry.

Main Results:

  • NE-IBU demonstrated significantly smaller particle size (31.3 nm) compared to EM-IBU (235.4 nm).
  • NE-IBU exhibited a lower polydispersity index (0.16 vs 0.23) and a more negative zeta potential (-25.8 mV vs -22.1 mV).
  • NE-IBU showed higher density (0.989 g cm⁻³) and superior colloidal and pH stability, indicating enhanced physicochemical robustness.

Conclusions:

  • The physicochemical properties of IBU polymorphs significantly impact drug delivery system performance.
  • Nanoemulsion formulation (NE-IBU) offers superior colloidal stability and physicochemical robustness for hydrophobic drug delivery.
  • NE-IBU holds considerable pharmaceutical potential for enhancing the delivery of poorly soluble drugs like ibuprofen.