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Risk factors for co-infections of helicobacter pylori and intestinal parasites: a cross-sectional study
Pourya Mohammadi1, Keyghobad Ghadiri2, Mosayeb Rostamian2
1Qazvin University of Medical Sciences, Gazvin, Iran.
Background And Objective:
Helicobacter (H.) pylori is one of the most prevalent bacterial infections worldwide, alongside intestinal parasitic infections, both posing significant public health risks. This research investigates the frequency of co-infections involving H. pylori and intestinal parasites while determining associated impacts.
Methods:
In this cross-sectional study, 240 patients from Imam Reza Clinic in Kermanshah (Dec 2023-Apr 2024) were included. Stool samples were tested for H. pylori by ELISA and intestinal parasites by microscopy and staining. Demographic data, diet, water source, and gastrointestinal symptoms were collected via questionnaire. Data were analyzed using chi-square and logistic regression in SPSS 21.
Results:
Of 240 patients, 43.3% had H. pylori infection, and intestinal parasites were detected in 24.2%. Occupation, age, vegetarian diet, and drinking water source were significantly associated with H. pylori infection alone. Findings suggested some parasites may increase H. pylori risk; however, this was not statistically confirmed. Logistic regression identified age and gastrointestinal symptoms as predictors of co-infection. Risk was highest in the 40-49 age group (OR=7.54, p=0.029); no significant associations were found in older groups (OR=4.08, p=0.148; OR=5.68, p=0.060). Multiple gastrointestinal symptoms significantly increased co-infection likelihood (OR=6.18, p=0.008). Gender (OR=1.65, p=0.267), diet (OR=1.98, p=0.134), occupation (OR=0.86, p=0.783), and water source (OR=0.21, p=0.127) showed no significant results.
Conclusion:
Co-infections of H. pylori were found in 10.8% of patients. Age and gastrointestinal symptoms were key predictors, while gender, water source, occupation, and residence showed no significant influence.
Insights
Helicobacter pylori and intestinal parasite co-infections affect over 10% of patients, with age and gastrointestinal symptoms being key predictors. Understanding these co-infections is crucial for public health strategies.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Public Health
Background:
- Helicobacter pylori (H. pylori) and intestinal parasitic infections are globally prevalent, presenting significant public health challenges.
- Co-infections with H. pylori and intestinal parasites are common, necessitating research into their frequency and impact.
Purpose of the Study:
- To investigate the prevalence of co-infections between H. pylori and intestinal parasites.
- To determine the factors associated with these co-infections and their impact on patients.
Main Methods:
- A cross-sectional study involving 240 patients from Imam Reza Clinic.
- Stool sample analysis for H. pylori (ELISA) and intestinal parasites (microscopy/staining).
- Data collection via questionnaires on demographics, diet, water source, and symptoms; analysis using chi-square and logistic regression.
Main Results:
- H. pylori infection was found in 43.3% and intestinal parasites in 24.2% of patients.
- Co-infections were present in 10.8% of patients.
- Age and gastrointestinal symptoms were significant predictors of co-infection, with the 40-49 age group showing the highest risk.
Conclusions:
- Age and gastrointestinal symptoms are key predictors of H. pylori and intestinal parasite co-infections.
- While some parasites may increase H. pylori risk, this was not statistically confirmed.
- Public health interventions should consider age and gastrointestinal health in managing these co-infections.
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