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Obstructive Sleep Apnea Is Associated with Increased Myocardial Scar Burden in Patients with Obstructive Hypertrophic

Shengwei Wang1, Hongchang Guo1, Ke Zhang1

  • 1Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Vascular Blood Diseases, Beijing, China.

CJC Open
|March 16, 2026
PubMed

Insights

Obstructive sleep apnea (OSA) is linked to more myocardial scarring in hypertrophic cardiomyopathy (HCM) patients. Increased OSA severity correlates with greater scar burden, suggesting a need for further investigation into OSA treatment effects.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Medical Imaging

Background:

  • Obstructive sleep apnea (OSA) is common in hypertrophic cardiomyopathy (HCM) patients.
  • Late gadolinium enhancement (LGE) indicates myocardial scarring and predicts adverse events in HCM.
  • The relationship between OSA and myocardial scar burden in HCM is not well understood.

Purpose of the Study:

  • To investigate the association between obstructive sleep apnea (OSA) and myocardial scar burden in patients with obstructive hypertrophic cardiomyopathy (HCM).

Main Methods:

  • Prospective study of 223 obstructive HCM patients.
  • Utilized polysomnography and cardiac magnetic resonance (CMR) imaging with LGE quantification.
  • Analyzed LGE% in relation to OSA severity (AHI) and clinical variables.

Main Results:

  • Myocardial scarring (LGE%) increased significantly with OSA severity (p < 0.001).
  • Higher apnea-hypopnea index (AHI) correlated with increased LGE%.
  • OSA presence and severity were independently associated with LGE% after adjusting for covariates.

Conclusions:

  • OSA presence and severity are associated with increased myocardial scarring in obstructive HCM.
  • Further research is warranted to determine if OSA treatment impacts clinical outcomes in this population.
Abstract

Keywords:
hypertrophic cardiomyopathylate gadolinium enhancementmyocardial scarobstructive sleep apnea

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